Acute and post-acute multidisciplinary outcomes of newborns born from mothers with SARS-CoV-2 infection during pregnancy or the perinatal period
Danilo Buonsenso,
Giulia Poretti,
Francesco Mariani,
Arianna Turriziani Colonna,
Simonetta Costa,
Lucia Giordano,
Francesca Priolo,
Guido Conti,
Angelo Tizio,
Daniela Rodolico,
Giulia Maria Amorelli,
Lorenzo Orazi,
Maria Petrianni,
Daniela Ricci,
Antonio Lanzone,
Maurizio Sanguinetti,
Paola Cattani,
Francesca Raffaelli,
Michela Sali,
Giuseppe Zampino,
Giovanni Vento,
Piero Valentini
Affiliations
Danilo Buonsenso
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Global Health Research Institute, Istituto di Igiene, Università Cattolica Del Sacro Cuore, Rome, Italy; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Microbiologia, Università Cattolica Del Sacro Cuore, Rome, Italy; Corresponding author. Largo A. Gemelli 8, 00168, Rome, Italy.
Giulia Poretti
Medicine and Surgery, Università Cattolica Del Sacro Cuore, 00168 Rome, Italy
Francesco Mariani
Pediatric Resident, Università Cattolica Del Sacro Cuore, 00168 Rome, Italy
Arianna Turriziani Colonna
Pediatric Resident, Università Cattolica Del Sacro Cuore, 00168 Rome, Italy
Simonetta Costa
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
Lucia Giordano
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
Francesca Priolo
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
Guido Conti
Institute of Otorhinolaryngology, Università Cattolica Del Sacro Cuore, Fondazione Policlinico “A Gemelli”, IRCCS, Rome, Italy
Angelo Tizio
Institute of Otorhinolaryngology, Università Cattolica Del Sacro Cuore, Fondazione Policlinico “A Gemelli”, IRCCS, Rome, Italy
Daniela Rodolico
Institute of Otorhinolaryngology, Università Cattolica Del Sacro Cuore, Fondazione Policlinico “A Gemelli”, IRCCS, Rome, Italy
Giulia Maria Amorelli
Department of Ophthalmology, Gemelli Foundation IRCSS, Catholic University of the Sacred Heart, Rome, Italy; National Centre of Services and Research for the Prevention of Blindness and Rehabilitation of Low Vision Patients, IAPB Italia Onlus- Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy
Lorenzo Orazi
Department of Ophthalmology, Gemelli Foundation IRCSS, Catholic University of the Sacred Heart, Rome, Italy
Maria Petrianni
Department of Ophthalmology, Gemelli Foundation IRCSS, Catholic University of the Sacred Heart, Rome, Italy
Daniela Ricci
Department of Ophthalmology, Gemelli Foundation IRCSS, Catholic University of the Sacred Heart, Rome, Italy
Antonio Lanzone
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
Maurizio Sanguinetti
Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Microbiologia, Università Cattolica Del Sacro Cuore, Rome, Italy; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
Paola Cattani
Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Microbiologia, Università Cattolica Del Sacro Cuore, Rome, Italy; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
Francesca Raffaelli
Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
Michela Sali
Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Sezione di Microbiologia, Università Cattolica Del Sacro Cuore, Rome, Italy; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
Giuseppe Zampino
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
Giovanni Vento
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
Piero Valentini
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy
Introduction.We performed a single-center, prospective, observational study of newborns born from mothers with microbiologically confirmed SARS-CoV-2 infection in pregnancy or at time of delivery to evaluate acute and mid-term multidisciplinary outcomes.Methods.Infants were offered a multidisciplinary follow-up consisting of nasopharyngeal Polymerase Chain Reaction test at birth and at 48–72 h of life, auxological and ophthalmological assessments, and serologic testing.Results.791 women and their 791 children (52.3% males) were included. Most placentas (94.9%) had abnormal inflammatory findings. 171 (27.3%) and 36 (13.7%) children respectively had pathological TEOAEs in at least one ear and bilaterally, while only four of the 85 children that underwent ABR had pathological findings (4.7%). 64 children underwent fluorescein angiography, which resulted pathological only in 1 case (1.6%). Anti-SARS-CoV-2 IgGs were found in up to 60% of children tested at six months of age. Our findings showed no association between the maternal vaccination status or the presence of maternal symptoms during pregnancy and neonatal outcomes.Conclusions.Our study shows that the large majority of newborns exposed to SARS-CoV-2 infection in utero or during the first hours of life have optimal outcomes. Our previous report of abnormal ophthalmologic findings was not confirmed on a larger cohort, while further studies are needed to better characterize audiological outcomes. Further prospective, case-controlled studies are still needed.
