PHARMACOLOGICAL PRECONDITIONING. FOCUS ON NICORANDIL

Abstract

The review focuses on the gathered data related to preconditioning phenomenon and, particularly, pharmacological preconditioning of myocardium. The information presented, on the activator of ATP-dependent potassium channels nicorandil. Mechanism of action is discussed, as efficacy and safety data. The evidence shows that, recently, nicorandil is not an obligatory medication to follow percutaneous intervention on coronary arteries, though clinical trials data confirm the possibility of periprocedural myocardium damage risk reduction, if the drug is prescribed in advance. The data presented, on positive influence of nicorandil on myocardial contractility and clinical outcomes.

Keywords

• pharmacological preconditioning of myocardium
• nicorandil
• activator of atp-dependent potassium channels
• percutaneous coronary interventions
• cardiac enzymes