Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp.
Ying Liu,
Shizhe Zhao,
Wanjing Ding,
Pinmei Wang,
Xianwen Yang,
Jinzhong Xu
Affiliations
Ying Liu
Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China
Shizhe Zhao
Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China
Wanjing Ding
Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China
Pinmei Wang
Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China
Xianwen Yang
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Jinzhong Xu
Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China
Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. Apochalasin V showed moderate activity at IC50 values of 30.4 and 39.2 μM, respectively.
