Nature Communications (Sep 2018)
Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
- Cai Zhang,
- Joonbae Seo,
- Kazutoshi Murakami,
- Esam S. B. Salem,
- Elise Bernhard,
- Vishnupriya J. Borra,
- Kwangmin Choi,
- Celvie L. Yuan,
- Calvin C. Chan,
- Xiaoting Chen,
- Taosheng Huang,
- Matthew T. Weirauch,
- Senad Divanovic,
- Nathan R. Qi,
- Hala Einakat Thomas,
- Carol A. Mercer,
- Haruhiko Siomi,
- Takahisa Nakamura
Affiliations
- Cai Zhang
- Division of Endocrinology, Cincinnati Children’s Hospital Medical Center
- Joonbae Seo
- Division of Endocrinology, Cincinnati Children’s Hospital Medical Center
- Kazutoshi Murakami
- Division of Endocrinology, Cincinnati Children’s Hospital Medical Center
- Esam S. B. Salem
- Division of Endocrinology, Cincinnati Children’s Hospital Medical Center
- Elise Bernhard
- Division of Endocrinology, Cincinnati Children’s Hospital Medical Center
- Vishnupriya J. Borra
- Division of Endocrinology, Cincinnati Children’s Hospital Medical Center
- Kwangmin Choi
- Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center
- Celvie L. Yuan
- Division of Endocrinology, Cincinnati Children’s Hospital Medical Center
- Calvin C. Chan
- Medical Scientist Training Program, Immunology Graduate Program, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine
- Xiaoting Chen
- Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center
- Taosheng Huang
- Department of Pediatrics, University of Cincinnati College of Medicine
- Matthew T. Weirauch
- Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center
- Senad Divanovic
- Department of Pediatrics, University of Cincinnati College of Medicine
- Nathan R. Qi
- Department of Internal Medicine, University of Michigan Medical School
- Hala Einakat Thomas
- Division of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine
- Carol A. Mercer
- Division of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine
- Haruhiko Siomi
- Department of Molecular Biology, Keio University School of Medicine
- Takahisa Nakamura
- Division of Endocrinology, Cincinnati Children’s Hospital Medical Center
- DOI
- https://doi.org/10.1038/s41467-018-05870-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The RNA-induced silencing complex (RISC) represses gene expression via micro-RNA guided mRNA silencing. Here, the authors show that RISC component Argonaute 2 in the liver regulates energy metabolism by inducing microRNAs that cause metabolic disruption and by suppressing protein translation linked to AMPK activation.
