Total serum IgE levels in soil-transmitted helminth infected children with atopy symptoms

Abstract

Background High total serum immunoglobulin E (IgE) levels and eosinophilia are markers for atopy, but other factors may also play a key role in affecting atopy, such as intestinal parasitic infection. Helminthiasis has been associated with a reduced risk of atopy and asthma symptoms in areas with high prevalence of parasitic infections. Objective To assess for associations between total serum IgE level and soil-transmitted helminthiasis (STH) infection, as well as between STH infection and allergy symptoms. Methods We conducted a cross-sectional stu dy on 84 consecutively-enrolled children , aged 7- 13 years, in the Secanggang Subdistrict, Langkat District, North Sumatera Province. Subjects were enrolled into one of two groups, with or without STH infection. Total serum IgE measurements and stool STH examinations were performed in all subjects. Data on atopy or allergy symptoms were obtained by parental interview. Results The 42 subjects with STH infection had significantly higher mean total serum lg E levels than the 42 subjects without infec tion, 1,13 1.26 IU/mL and 744.76 IU/mL, respectiv ely (P = 0.029). We also fo und significant positive association s between STH infection and asthma symptoms (P= 0.049), as well as eczema symptoms (P=0.044). Conclusion Mean total serum IgE level is higher in STHinfected subjects than in those without infection. In addition, STH infection is positively associated with asthma and eczema symptoms.

Keywords

• totalserum igE, soil- transmittedhelminth infection, atopy, children