Exploring TRIM proteins’ role in antiviral defense against influenza A virus and respiratory coronaviruses

Ying Wei; Ying Wei; Ying Wei; Junzhu Song; Junzhu Song; Junzhu Song; Jingyu Zhang; Jingyu Zhang; Jingyu Zhang; Songbiao Chen; Songbiao Chen; Songbiao Chen; Zuhua Yu; Zuhua Yu; Zuhua Yu; Lei He; Lei He; Lei He; Jian Chen; Jian Chen; Jian Chen

doi:10.3389/fcimb.2024.1420854

Frontiers in Cellular and Infection Microbiology (Jul 2024)

Exploring TRIM proteins’ role in antiviral defense against influenza A virus and respiratory coronaviruses

Ying Wei,
Ying Wei,
Ying Wei,
Junzhu Song,
Junzhu Song,
Junzhu Song,
Jingyu Zhang,
Jingyu Zhang,
Jingyu Zhang,
Songbiao Chen,
Songbiao Chen,
Songbiao Chen,
Zuhua Yu,
Zuhua Yu,
Zuhua Yu,
Lei He,
Lei He,
Lei He,
Jian Chen,
Jian Chen,
Jian Chen

Affiliations

Ying Wei: Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Ying Wei: Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, China
Ying Wei: The Key Lab of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang, China
Junzhu Song: Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Junzhu Song: Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, China
Junzhu Song: The Key Lab of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang, China
Jingyu Zhang: Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Jingyu Zhang: Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, China
Jingyu Zhang: The Key Lab of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang, China
Songbiao Chen: Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Songbiao Chen: Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, China
Songbiao Chen: The Key Lab of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang, China
Zuhua Yu: Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Zuhua Yu: Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, China
Zuhua Yu: The Key Lab of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang, China
Lei He: Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Lei He: Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, China
Lei He: The Key Lab of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang, China
Jian Chen: Laboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
Jian Chen: Luoyang Key Laboratory of Live Carrier Biomaterial and Animal Disease Prevention and Control, Henan University of Science and Technology, Luoyang, China
Jian Chen: The Key Lab of Animal Disease and Public Health, Henan University of Science and Technology, Luoyang, China

DOI: https://doi.org/10.3389/fcimb.2024.1420854
Journal volume & issue: Vol. 14

Abstract

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Numerous tripartite motif (TRIM) proteins, identified as E3 ubiquitin ligases, participate in various viral infections through ubiquitylation, ISGylation, and SUMOylation processes. Respiratory viruses, particularly influenza A virus (IAV) and respiratory coronaviruses (CoVs), have severely threatened public health with high morbidity and mortality, causing incalculable losses. Research on the regulation of TRIM proteins in respiratory virus infections is crucial for disease prevention and control. This review introduces TRIM proteins, summarizes recent discoveries regarding their roles and molecular mechanisms in IAV and CoVs infections, discusses current research gaps, and explores potential future trends in this rapidly developing field. It aims to enhance understanding of virus–host interactions and inform the development of new molecularly targeted therapies.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

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