Nature Communications (Jun 2017)
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
- Xiaowen Zhang,
- Huai-Chin Chiang,
- Yao Wang,
- Chi Zhang,
- Sabrina Smith,
- Xiayan Zhao,
- Sreejith J. Nair,
- Joel Michalek,
- Ismail Jatoi,
- Meeghan Lautner,
- Boyce Oliver,
- Howard Wang,
- Anna Petit,
- Teresa Soler,
- Joan Brunet,
- Francesca Mateo,
- Miguel Angel Pujana,
- Elizabeth Poggi,
- Krysta Chaldekas,
- Claudine Isaacs,
- Beth N. Peshkin,
- Oscar Ochoa,
- Frederic Chedin,
- Constantine Theoharis,
- Lu-Zhe Sun,
- Tyler J. Curiel,
- Richard Elledge,
- Victor X. Jin,
- Yanfen Hu,
- Rong Li
Affiliations
- Xiaowen Zhang
- Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
- Huai-Chin Chiang
- Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
- Yao Wang
- Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
- Chi Zhang
- Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
- Sabrina Smith
- Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
- Xiayan Zhao
- Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
- Sreejith J. Nair
- Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
- Joel Michalek
- Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio
- Ismail Jatoi
- Department of Surgery, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio
- Meeghan Lautner
- Department of Surgery, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio
- Boyce Oliver
- Department of Surgery, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio
- Howard Wang
- Department of Surgery, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio
- Anna Petit
- Department of Pathology, University Hospital of Bellvitge, Bellvitge Institute for Biomedical Research (IDIBELL), L’Hospitalet del Llobregat
- Teresa Soler
- Department of Pathology, University Hospital of Bellvitge, Bellvitge Institute for Biomedical Research (IDIBELL), L’Hospitalet del Llobregat
- Joan Brunet
- Hereditary Cancer Program, Catalan Institute of Oncology (ICO), Girona Biomedical Research Institute (IDIBGI)
- Francesca Mateo
- Breast Cancer and Systems Biology Lab, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L’Hospitalet del Llobregat
- Miguel Angel Pujana
- Breast Cancer and Systems Biology Lab, Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L’Hospitalet del Llobregat
- Elizabeth Poggi
- Lombardi Comprehensive Cancer Center, Georgetown University
- Krysta Chaldekas
- Lombardi Comprehensive Cancer Center, Georgetown University
- Claudine Isaacs
- Lombardi Comprehensive Cancer Center, Georgetown University
- Beth N. Peshkin
- Lombardi Comprehensive Cancer Center, Georgetown University
- Oscar Ochoa
- PRMA Plastic Surgery
- Frederic Chedin
- Department of Molecular and Cellular Biology, University of California
- Constantine Theoharis
- South Texas Pathology Associates
- Lu-Zhe Sun
- Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio
- Tyler J. Curiel
- Department of Medicine, University of Texas Health Science Center at San Antonio
- Richard Elledge
- Department of Medicine, University of Texas Health Science Center at San Antonio
- Victor X. Jin
- Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
- Yanfen Hu
- Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
- Rong Li
- Department of Molecular Medicine, University of Texas Health Science Center at San Antonio
- DOI
- https://doi.org/10.1038/ncomms15908
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
The vast majority of BRCA1-driven breast cancers derive from luminal progenitor cells but the mechanisms of this lineage specificity are unclear. Here the authors show that dangerous accumulation of DNA-RNA hybrid structures due to RNA polymerase II pausing, occurs specifically in luminal epithelial cells.
