Communications Chemistry (Feb 2022)

The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces

  • Doris A. van Bergeijk,
  • Somayah S. Elsayed,
  • Chao Du,
  • Isabel Nuñez Santiago,
  • Anna M. Roseboom,
  • Le Zhang,
  • Victor J. Carrión,
  • Herman P. Spaink,
  • Gilles P. van Wezel

DOI
https://doi.org/10.1038/s42004-022-00632-4
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 12

Abstract

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The biosynthetic gene clusters of Actinobacteria are poorly expressed in the laboratory, necessitating a better understanding of the signals that promote their expression in order to exploit their full biosynthetic potential. Here, the authors show that the stress hormone epinephrine elicits the expression of biosynthetic gene clusters and influences the metabolism of Streptomyces, with the catechol moiety proving key to this response.