Molecular mechanism of antibody neutralization of coxsackievirus A16

Chao Zhang; Caixuan Liu; Jinping Shi; Yalei Wang; Cong Xu; Xiaohua Ye; Qingwei Liu; Xue Li; Weihua Qiao; Yannan Yin; Yao Cong; Zhong Huang

doi:10.1038/s41467-022-35575-w

Nature Communications (Dec 2022)

Molecular mechanism of antibody neutralization of coxsackievirus A16

Chao Zhang,
Caixuan Liu,
Jinping Shi,
Yalei Wang,
Cong Xu,
Xiaohua Ye,
Qingwei Liu,
Xue Li,
Weihua Qiao,
Yannan Yin,
Yao Cong,
Zhong Huang

Affiliations

Chao Zhang: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Caixuan Liu: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Jinping Shi: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Yalei Wang: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Cong Xu: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Xiaohua Ye: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Qingwei Liu: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Xue Li: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Weihua Qiao: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Yannan Yin: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences
Yao Cong: State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Zhong Huang: CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-35575-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Coxsackievirus A16 (CVA-16) causes hand, food and mouth disease in infants and young children, however, currently there are neither anti-virals nor vaccines available for treatment. Here, Zhang et al. characterize two CVA16-specific neutralizing monoclonal antibodies, 9B5 and 8C4. They provide evidence for their prophylactic and therapeutic application in vivo in mice and perform CryoEM to show that both antibodies target different epitopes on the viral capsid.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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