Successful management of testicular primitive neuroectodermal tumor with multiple bone metastases

Abstract

Introduction Germ cell tumor with malignant transformation is extremely rare. We present a case of testicular primitive neuroectodermal tumor with multiple metastases that was effectively managed by surgery, irradiation, and second‐line chemotherapy. Case presentation A 22‐year‐old man was diagnosed as having teratoma including primitive neuroectodermal tumor with lymph node and multiple bone metastases. Five months afterwards the first‐line therapy, his skull metastasis recurred. Vincristine, doxorubicin, and cyclophosphamide therapy followed by vincristine, actinomycin D, and cyclophosphamide therapy was given as second‐line chemotherapy. Computed tomography revealed no disease progression 3 months after the treatments. Conclusion Metastatic primitive neuroectodermal tumor may be successfully managed by multidisciplinary cancer treatment.

Keywords

• chemotherapy
• germ cell tumor
• malignant transformation of teratoma
• primitive neuroectodermal tumor