The osteoplastic effect of Y500R coral hydroxyapatite composite grafts with fluoride on the rabbit skull

Abstract

Objective To explore the effect and changes in osteogenesis efficacy of CHA (Coral hydroxyapatite) com⁃ posite grafts with fluoride in guided bone augmentation on rabbit skull. Methods Twenty ⁃ four rabbits were studied. Y500R CHA composite grafts contained fluoride and titanium cylinders were prepared. Two titanium cylinders on the test group's rabbit skull were filled with composite grafts contain fluoride and non⁃fluoride grafts were filled in the control group. Cyclomycin and calcein were injected, After 2, 4 and 6 weeks, the animals were sacrificed to obtain ground sec⁃ tions for histology and histomorphometry. The general observation and area of highly fluorescent band of new bone forma⁃ tion was measured after sample treatment. Results Significantly more neogenesis bone was augmented in the test groups than the control group. The osteoplastic effect in the test group more athletic. The experimental data had statistical signifi⁃ cance (F = 6.36, P = 0.019 3). Conclusion Low concentration (1.0 × 10⁃7 mol/L ～ 5.0 × 10⁃5 mol/L) fluoride can pro⁃ mote bone formation effectively.

Keywords

• Fluoride，
• Coral hydroxyapatite，
• Bone substitute，
• Osteogenesis effect，
• Itanium cylinder􀆳s barrier，