Nature Communications (Feb 2022)
An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia
- Ifat Geron,
- Angela Maria Savino,
- Hila Fishman,
- Noa Tal,
- John Brown,
- Virginia A. Turati,
- Chela James,
- Jolanda Sarno,
- Michal Hameiri-Grossman,
- Yu Nee Lee,
- Avigail Rein,
- Hillary Maniriho,
- Yehudit Birger,
- Anna Zemlyansky,
- Inna Muler,
- Kara L. Davis,
- Victoria Marcu-Malina,
- Nicole Mattson,
- Oren Parnas,
- Rabea Wagener,
- Ute Fischer,
- João T. Barata,
- Catriona H. M. Jamieson,
- Markus Müschen,
- Chun-Wei Chen,
- Arndt Borkhardt,
- Ilan Richard Kirsch,
- Arnon Nagler,
- Tariq Enver,
- Shai Izraeli
Affiliations
- Ifat Geron
- Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University
- Angela Maria Savino
- Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University
- Hila Fishman
- Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University
- Noa Tal
- Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University
- John Brown
- Department of Cancer Biology, UCL Cancer Institute, UCL
- Virginia A. Turati
- Department of Cancer Biology, UCL Cancer Institute, UCL
- Chela James
- Department of Cancer Biology, UCL Cancer Institute, UCL
- Jolanda Sarno
- Department of Pediatrics, Bass Center for Childhood Cancer and Blood Disorders, Stanford University
- Michal Hameiri-Grossman
- The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children’s Medical Center of Israel
- Yu Nee Lee
- Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University
- Avigail Rein
- Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University
- Hillary Maniriho
- Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University
- Yehudit Birger
- Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University
- Anna Zemlyansky
- The Rina Zaizov Pediatric Hematology and Oncology Division Schneider Children’s Medical Center of Israel
- Inna Muler
- Institute of Pediatric Research, Edmond and Lily Safra Children’s Hospital, Chaim Sheba Medical Center
- Kara L. Davis
- Department of Pediatrics, Bass Center for Childhood Cancer and Blood Disorders, Stanford University
- Victoria Marcu-Malina
- Cytogenetic Unit laboratory of Hematology, Chaim Sheba Medical Center Tel Hashomer
- Nicole Mattson
- Department of Systems Biology, City of Hope Comprehensive Cancer Center
- Oren Parnas
- The Concern Foundation Laboratories at the Lautenberg Center for immunology and Cancer Research, IMRIC, Hebrew University Faculty of Medicine
- Rabea Wagener
- Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf
- Ute Fischer
- Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf
- João T. Barata
- Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa
- Catriona H. M. Jamieson
- UC San Diego, Moores Cancer Center, Division of Regenerative Medicine, Department of Medicine and Sanford Stem Cell Clinical Center
- Markus Müschen
- Department of Systems Biology, City of Hope Comprehensive Cancer Center
- Chun-Wei Chen
- Department of Systems Biology, City of Hope Comprehensive Cancer Center
- Arndt Borkhardt
- Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf
- Ilan Richard Kirsch
- Adaptive Biotechnologies, Inc.
- Arnon Nagler
- Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University
- Tariq Enver
- Department of Cancer Biology, UCL Cancer Institute, UCL
- Shai Izraeli
- Felsenstein Medical Research Center and The Molecular Genetics and Biochemistry Department, Sackler Faculty of Medicine, Tel Aviv University
- DOI
- https://doi.org/10.1038/s41467-022-28218-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 12
Abstract
Activating mutations in Interleukin-7 receptor alpha (IL7Ra) have been reported in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) but its role in leukaemogenesis is not clear. Here, the authors show that activation of IL7Ra in primary human hematopoietic progenitors initiates preleukaemia and cooperates with CDKN2A silencing to develop BCP-ALL.
