THE INFLUENCE OF COMPETITION DRUGS FOR THE TREATMENT OF HYPERTENSION IN PATIENTS WITH TYPE 2 DIABETES

Abstract

The question of the effect of drug competition on the effectiveness of treatment of arterial hypertension (AH ) in type 2 diabetes mellitus (DM ) is very urgent and requires in-depth study. Until now, it has not been established how the prescription of drugs, taking into account their competition in the liver, will affect the achievement of target blood pressure in patients with type 2 diabetes. This was the reason for the study. The aim of the study – to improve the achievement of target blood pressure in patients with type 2 diabetes mellitus. Materials and Methods. The main group consisted of 35 patients with arterial hypertension and type 2 diabetes mellitus who received treatment at the Therapeutic Departments of the Lviv Municipal Emergency Hospital No. 1 and No. 2. Results and Discussion. The control group consisted of 74 people with type 2 diabetes and hypertension who were treated without taking into account inter-drug competition in the cytochrome P-450 system. In 26 among 35 (74 %) patients in the main group treated with medicamental mediated by Cyp-450, the target blood pressure was achieved. In the control group, taking drugs without taking this interaction into account, the target blood pressure was achieved only in 33 patients (44.6 %). It has been established that the treatment of hypertension with type 2 diabetes, conducted taking into account the interaction of drugs in the cytochrome P-450 system, is significantly more effective than therapy without taking this interaction into account. Conclusions. To optimize the correction of blood pressure in patients with type 2 diabetes, it is necessary to prescribe antihypertensive drugs that do not compete with hypoglycemic drugs in the liver.

Keywords

• цукровий діабет 2 типу
• артеріальна гіпертензія
• конкуренція медикаментів
• цитохром P-450.