Three dimensional reconstruction of the mouse cerebellum in Hedgehog-driven medulloblastoma models to identify Norrin-dependent effects on preneoplasia

Nenad T. Pokrajac; Akshay Gurdita; Nobuhiko Tachibana; Nicholas J. A. Tokarew; Valerie A. Wallace

doi:10.1038/s42003-022-03507-5

Communications Biology (Jun 2022)

Three dimensional reconstruction of the mouse cerebellum in Hedgehog-driven medulloblastoma models to identify Norrin-dependent effects on preneoplasia

Nenad T. Pokrajac,
Akshay Gurdita,
Nobuhiko Tachibana,
Nicholas J. A. Tokarew,
Valerie A. Wallace

Affiliations

Nenad T. Pokrajac: Donald K. Johnson Eye Institute, Krembil Research Institute, University Health Network
Akshay Gurdita: Donald K. Johnson Eye Institute, Krembil Research Institute, University Health Network
Nobuhiko Tachibana: Donald K. Johnson Eye Institute, Krembil Research Institute, University Health Network
Nicholas J. A. Tokarew: Donald K. Johnson Eye Institute, Krembil Research Institute, University Health Network
Valerie A. Wallace: Donald K. Johnson Eye Institute, Krembil Research Institute, University Health Network

DOI: https://doi.org/10.1038/s42003-022-03507-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Light sheet fluorescent microscopy can successfully be used to quantify preneoplastic alteration of tissue in mouse medulloblastoma, providing an alternative approach for 3D analysis of tumour initiation events in mice.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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