Pervasive translation of circular RNAs driven by short IRES-like elements

Xiaojuan Fan; Yun Yang; Chuyun Chen; Zefeng Wang

doi:10.1038/s41467-022-31327-y

Nature Communications (Jun 2022)

Pervasive translation of circular RNAs driven by short IRES-like elements

Xiaojuan Fan,
Yun Yang,
Chuyun Chen,
Zefeng Wang

Affiliations

Xiaojuan Fan: Bio-med Big Data Center, CAS Key Laboratory of Computational Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health
Yun Yang: Bio-med Big Data Center, CAS Key Laboratory of Computational Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health
Chuyun Chen: Bio-med Big Data Center, CAS Key Laboratory of Computational Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health
Zefeng Wang: Bio-med Big Data Center, CAS Key Laboratory of Computational Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health

DOI: https://doi.org/10.1038/s41467-022-31327-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Unbiased screen of random sequences identified many short IRES-like elements to drive circular RNA translation and hundreds of rolling circle translation events, suggesting a pervasive cap-independent translation in human transcriptome.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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