Онкогематология (Nov 2022)

Analysis of incidence and prognostic significance <i>FLT3, c-KIT</i> and <i>NPM1</i> genes mutation in children with acute myeloid leukemia

  • L. V. Guk,
  • T. V. Savitskaya,
  • D. A. Domninsky,
  • V. O. Bobrinina,
  • M. M. Schneider,
  • A. A. Maschan,
  • O. V. Aleinikova

DOI
https://doi.org/10.17650/1818-8346-2009-0-4-27-32
Journal volume & issue
Vol. 0, no. 4
pp. 27 – 32

Abstract

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Prognosis of patients with acute myeloid leukemia receiving intensive chemotherapy is defined as kariotyping anomalies, and mutations of genes responsible for surviving and self-maintenance leukemic cells. In the giving work incidence of mutation involving genes FLT3, c-KIT, NPM1 having prognostic value in adults is analysed. Kynase domain FLT3 mutation in 18 from 83 patients (21.6%) was detected. 2 from 18 patients (11%) achieved complete remission, 5 from 18 patients (27.7%) with FLT3 mutations were refractory to therapy, two patients died from treatment complications, 9 from 18 (50%) relapsed. Only 2 patients (11%) are alive in continuous complete remission. с-KIT mutations detected in 14.2% (2/14 patients), and NPM1 mutations represented allelic polymorphism. Thus, kynase domain FLT3 mutation are prognostic unfavorable.

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