Frontiers in Nutrition (Dec 2023)

Changes in the urinary proteome of rats after short-term intake of magnesium L-threonate(MgT)

  • Ziyun Shen,
  • Minhui Yang,
  • Haitong Wang,
  • Yuqing Liu,
  • Youhe Gao

DOI
https://doi.org/10.3389/fnut.2023.1305738
Journal volume & issue
Vol. 10

Abstract

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IntroductionMagnesium (Mg) is an important mineral in living organisms. Magnesium has multiple functions in the human body, wherein it plays an important therapeutic and preventive role in a variety of diseases.MethodsUrine samples of rats before and after gavage of magnesium L-threonate (MgT) were collected, and the urinary proteome was identified using the LC-MS/MS technique and analyzed using various databases.Results and discussionThe results illustrated that the urinary proteome of rats was significantly altered after short-term intake of magnesium supplements and that the differential proteins and the biological functions were related to magnesium. This study innovatively establishes a method to study nutrients from the perspective of urine proteomics. This work demonstrates that the urinary proteome is capable of reflecting the effects of nutrient intake on the organism in a more systematic and comprehensive manner and has the potential to provide clues for clinical nutrition research and practice.

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