Nature Communications (Jul 2020)

Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction

  • Lars-Lennart Oettl,
  • Max Scheller,
  • Carla Filosa,
  • Sebastian Wieland,
  • Franziska Haag,
  • Cathrin Loeb,
  • Daniel Durstewitz,
  • Roman Shusterman,
  • Eleonora Russo,
  • Wolfgang Kelsch

DOI
https://doi.org/10.1038/s41467-020-17257-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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It is not entirely understood how network plasticity produces the coding of predicted value during stimulus-outcome learning. Here, the authors reveal a reinforcing loop in distributed limbic circuits, transforming sensory stimuli into reward prediction coding broadcasted by dopamine neurons to the brain.