Nature Communications (Apr 2018)

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

  • Boyi Zhang,
  • Da Fu,
  • Qixia Xu,
  • Xianling Cong,
  • Chunyan Wu,
  • Xiaoming Zhong,
  • Yushui Ma,
  • Zhongwei Lv,
  • Fei Chen,
  • Liu Han,
  • Min Qian,
  • Y. Eugene Chin,
  • Eric W. -F. Lam,
  • Paul Chiao,
  • Yu Sun

DOI
https://doi.org/10.1038/s41467-018-04010-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 19

Abstract

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In cancer the side effects of therapeutic agents can provoke senescence-associated secretory phenotype (SASP), which can drive cancer resistance. During the DNA damage response, transcription factor Zscan4 expression is elevated by an ATM-TRAF6-TAK1 axis leading to long term SASP in human stromal cells.