Nature Communications (Aug 2022)
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling
- Feng Xie,
- Xiaoxue Zhou,
- Peng Su,
- Heyu Li,
- Yifei Tu,
- Jinjin Du,
- Chen Pan,
- Xiang Wei,
- Min Zheng,
- Ke Jin,
- Liyan Miao,
- Chao Wang,
- Xuli Meng,
- Hans van Dam,
- Peter ten Dijke,
- Long Zhang,
- Fangfang Zhou
Affiliations
- Feng Xie
- Institutes of Biology and Medical Science, Soochow University
- Xiaoxue Zhou
- MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
- Peng Su
- MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
- Heyu Li
- MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
- Yifei Tu
- MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
- Jinjin Du
- MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
- Chen Pan
- MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
- Xiang Wei
- MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
- Min Zheng
- State Key Laboratory for Diagnostic and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease
- Ke Jin
- Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University
- Liyan Miao
- The first affiliated hospital of soochow university
- Chao Wang
- Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University
- Xuli Meng
- Department of Breast Surgery, Zhejiang Provincial People’s Hospital
- Hans van Dam
- Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center
- Peter ten Dijke
- Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center
- Long Zhang
- MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University
- Fangfang Zhou
- Institutes of Biology and Medical Science, Soochow University
- DOI
- https://doi.org/10.1038/s41467-022-31250-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Understanding the factors that hamper immune therapy in breast cancer may increase the range of patients who benefit. Here authors show that breast cancer cells produce and subsequently transfer active TGF-β type II receptors to CD8 + T cells to render them exhausted, thus paralyzing the anti-tumor immune response.
