Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response

Swechha M. Pokharel; Niraj K. Shil; Jeevan B. GC; Zachary T. Colburn; Su-Yu Tsai; Jesus A. Segovia; Te-Hung Chang; Smarajit Bandyopadhyay; Senthil Natesan; Jonathan C. R. Jones; Santanu Bose

doi:10.1038/s41467-019-09453-x

Nature Communications (Apr 2019)

Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response

Swechha M. Pokharel,
Niraj K. Shil,
Jeevan B. GC,
Zachary T. Colburn,
Su-Yu Tsai,
Jesus A. Segovia,
Te-Hung Chang,
Smarajit Bandyopadhyay,
Senthil Natesan,
Jonathan C. R. Jones,
Santanu Bose

Affiliations

Swechha M. Pokharel: Department of Veterinary Microbiology and Pathology, Washington State University
Niraj K. Shil: Department of Veterinary Microbiology and Pathology, Washington State University
Jeevan B. GC: Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceuticals Sciences, Washington State University
Zachary T. Colburn: School of Molecular Biosciences, Washington State University
Su-Yu Tsai: Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio
Jesus A. Segovia: Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio
Te-Hung Chang: Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio
Smarajit Bandyopadhyay: Molecular Biotechnology Core Laboratory, Lerner Research Institute, Cleveland Clinic
Senthil Natesan: Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceuticals Sciences, Washington State University
Jonathan C. R. Jones: School of Molecular Biosciences, Washington State University
Santanu Bose: Department of Veterinary Microbiology and Pathology, Washington State University

DOI: https://doi.org/10.1038/s41467-019-09453-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

Read online

Integrins are key modulators of cell adhesion and signaling. Here the authors show, unexpectedly, that a complex of integrins and the lipid 25-hydroxycholesterol induces FAK activation and proinflammatory cytokine production, thereby serving as an integral part of innate immunity regulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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