Nature Communications (Aug 2018)

Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi

  • Javier Emperador-Melero,
  • Vincent Huson,
  • Jan van Weering,
  • Christian Bollmann,
  • Gabriele Fischer von Mollard,
  • Ruud F. Toonen,
  • Matthijs Verhage

DOI
https://doi.org/10.1038/s41467-018-05699-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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Vti1a and Vti1b are SNARE proteins implicated in regulated secretion. Here the authors show that Vti1a and Vti1b control protein sorting at the Golgi, and targeting to the axon, and thereby indirectly control regulated secretion at the synapse.