Nature Communications (Jun 2021)
An antibody against L1 cell adhesion molecule inhibits cardiotoxicity by regulating persistent DNA damage
- Jae-Kyung Nam,
- A-Ram Kim,
- Seo-Hyun Choi,
- Ji-Hee Kim,
- Kyu Jin Choi,
- Seulki Cho,
- Jae Won Lee,
- Hyun-Jai Cho,
- Yoo-Wook Kwon,
- Jaeho Cho,
- Kwang Seok Kim,
- Joon Kim,
- Hae-June Lee,
- Tae Sup Lee,
- Sangwoo Bae,
- Hyo Jeong Hong,
- Yoon-Jin Lee
Affiliations
- Jae-Kyung Nam
- Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences
- A-Ram Kim
- Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences
- Seo-Hyun Choi
- Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences
- Ji-Hee Kim
- Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences
- Kyu Jin Choi
- Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences
- Seulki Cho
- Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University
- Jae Won Lee
- Biomedical Research Institute, Seoul National University Hospital
- Hyun-Jai Cho
- Biomedical Research Institute, Seoul National University Hospital
- Yoo-Wook Kwon
- Cardiovascular Center & Department of Internal Medicine, Seoul National University Hospital
- Jaeho Cho
- Department of Radiation Oncology, Yonsei University College of Medicine
- Kwang Seok Kim
- Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences
- Joon Kim
- Laboratory of Biochemistry, Division of Life Sciences, Korea University
- Hae-June Lee
- Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences
- Tae Sup Lee
- Division of RI Convergence Research, Korea Institute of Radiological & Medical Sciences
- Sangwoo Bae
- Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences
- Hyo Jeong Hong
- Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University
- Yoon-Jin Lee
- Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences
- DOI
- https://doi.org/10.1038/s41467-021-23478-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Mechanisms underlying the cardiotoxicity associated with thoracic irradiation and doxorubicin treatment during anticancer therapy remain poorly understood. Here the authors show that treatment with an antibody against the L1 cell adhesion molecule inhibits nuclear L1CAM translocation, thereby controlling vascular DNA damage and preventing cardiotoxicity.
