Zdorovʹe Rebenka (Mar 2012)

Evaluation of Hemopoietic Disorders and Renal Function in Children with Chronic Glomerulonephritis Depending on Allelic Gene Polymorphism of IL-10 and IL-1β

  • V.M. Dudnyk,
  • G.Yu. Zvenigorodska

DOI
https://doi.org/10.22141/2224-0551.0.3.38.2012.100651
Journal volume & issue
Vol. 7, no. 3.38
pp. 18 – 21

Abstract

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We have examined 20 children suffering from chronic glomerulonephritis with torpid course of disease and persistent urinary syndrome. It was defined that in children with torpid course of disease genotype C/T gene IL-1β (-511) (p < 0.05) was significantly more common. Also, we found the relationship between allelic variants of cytokines genes and parameters of GFR and endogenous erythropoietin. In children with genotype C/T IL-1β (-511) has been a significant reduction of erythropoietin even in the absence of anemia and iron deficiency (p < 0.05). In identifying the genotype G/G IL-10 (-1082) and C/T, C/C genotype of IL-1β (-511) 1.2-fold lower GFR was observed (p < 0.05).

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