Diagnosis of Rare Bone Infection Caused by Nocardia by 16S rRNA Gene Sequencing

Abstract

Shaozeng Li,1,* Yu Shi,1,* Yulin Xiong,1 Yali Liu2 1Department of Clinical Laboratory, the Fourth Medical Center of PLA General Hospital, Beijing, 100037, People’s Republic of China; 2Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yali Liu, Email [email protected]: Nocardia is an aerobic actinomycete that causes serious opportunistic infections in immunocompromised individuals. Gene sequencing is the gold standard for pathogenic bacteria diagnosis. This study uses 16S rRNA gene sequencing to diagnose three cases of bone infections caused by Nocardia, including one rare case (N. cyriacigeorgica), and the clinial features, etiological characteristics, treatment, and prognosis of the patients.Keywords: Nocardia, 16S rRNA gene sequencing, bone infection, clinical features

Keywords

• nocardia
• 16s rrna gene sequencing
• bone infection
• clinical features.