Communications Biology (Aug 2022)
Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor
- Elsie Diaz,
- Suraj Adhikary,
- Armand W. J. W. Tepper,
- Daniel Riley,
- Rodrigo Ortiz-Meoz,
- Daniel Krosky,
- Christophe Buyck,
- Carolina Martinez Lamenca,
- Josep Llaveria,
- Lichao Fang,
- Jay H. Kalin,
- Vincent N. A. Klaren,
- Shorouk Fahmy,
- Paul L. Shaffer,
- Robert Kirkpatrick,
- Rodrigo J. Carbajo,
- Maren Thomsen,
- Antonietta Impagliazzo
Affiliations
- Elsie Diaz
- Janssen Research & Development, Welsh & McKean Roads
- Suraj Adhikary
- Janssen Research & Development, Welsh & McKean Roads
- Armand W. J. W. Tepper
- Janssen Vaccine and Prevention
- Daniel Riley
- Janssen Research & Development, Welsh & McKean Roads
- Rodrigo Ortiz-Meoz
- Janssen Research & Development, Welsh & McKean Roads
- Daniel Krosky
- Janssen Research & Development, Welsh & McKean Roads
- Christophe Buyck
- Janssen Research & Development
- Carolina Martinez Lamenca
- Janssen Research & Development
- Josep Llaveria
- Janssen Research & Development, Janssen-Cilag
- Lichao Fang
- Janssen Research & Development Center Medicinal Chemistry
- Jay H. Kalin
- Janssen Research & Development, Welsh & McKean Roads
- Vincent N. A. Klaren
- Janssen Vaccine and Prevention
- Shorouk Fahmy
- Janssen Vaccine and Prevention
- Paul L. Shaffer
- Janssen Research & Development, Welsh & McKean Roads
- Robert Kirkpatrick
- Janssen Research & Development, Welsh & McKean Roads
- Rodrigo J. Carbajo
- Janssen Research & Development, Janssen-Cilag
- Maren Thomsen
- Proteros biostructures GmbH Bunsenstr 7a
- Antonietta Impagliazzo
- Janssen Vaccine and Prevention
- DOI
- https://doi.org/10.1038/s42003-022-03735-9
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
Rational engineering of human spermine oxidase yields crystallizable structures and the design of an allosteric inhibitor.
