Infection and Drug Resistance (Feb 2020)
The Battle of Probiotics and Their Derivatives Against Biofilms
Abstract
Abolfazl Barzegari,1,* Keyvan Kheyrolahzadeh,1,2,* Seyed Mahdi Hosseiniyan Khatibi,3,* Simin Sharifi,4 Mohammad Yousef Memar,5 Sepideh Zununi Vahed3 1Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran; 2Azad University, Tabriz, Iran; 3Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 4Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 5Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran*These authors contributed equally to this workCorrespondence: Sepideh Zununi VahedKidney Research Center, Tabriz University of Medical Sciences, Tabriz, IranTel +989140404242Email [email protected]: Biofilm-related infections have been a major clinical problem and include chronic infections, device-related infections and malfunction of medical devices. Since biofilms are not fully available for the human immune system and antibiotics, they are difficult to eradicate and control; therefore, imposing a global threat to human health. There have been avenues to tackle biofilms largely based on the disruption of their adhesion and maturation. Nowadays, the use of probiotics and their derivatives has gained a growing interest in battling against pathogenic biofilms. In the present review, we have a close look at probiotics with the ultimate objective of inhibiting biofilm formation and maturation. Overall, insights into the mechanisms by which probiotics and their derivatives can be used in the management of biofilm infections would be warranted.Keywords: antibiotic resistance, biofilm, probiotics, lactobacillus, sepsis, infection
