Emerging Impact of Non-coding RNAs in the Pathology of Stroke

Soudeh Ghafouri-Fard; Zeinab Shirvani-Farsani; Bashdar Mahmud Hussen; Mohammad Taheri; Noormohammad Arefian

doi:10.3389/fnagi.2021.780489

Frontiers in Aging Neuroscience (Nov 2021)

Emerging Impact of Non-coding RNAs in the Pathology of Stroke

Soudeh Ghafouri-Fard,
Zeinab Shirvani-Farsani,
Bashdar Mahmud Hussen,
Mohammad Taheri,
Noormohammad Arefian

Affiliations

Soudeh Ghafouri-Fard: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Zeinab Shirvani-Farsani: Department of Cell and Molecular Biology, Faculty of Life Sciences and Technology, Shahid Beheshti University, Tehran, Iran
Bashdar Mahmud Hussen: Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq
Mohammad Taheri: Institute of Human Genetics, Jena University Hospital, Jena, Germany
Noormohammad Arefian: Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University Hospital, Tehra, Iran

DOI: https://doi.org/10.3389/fnagi.2021.780489
Journal volume & issue: Vol. 13

Abstract

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Ischemic stroke (IS) is an acute cerebral vascular event with high mortality and morbidity. Though the precise pathophysiologic routes leading to this condition are not entirely clarified, growing evidence from animal and human experiments has exhibited the impact of non-coding RNAs in the pathogenesis of IS. Various lncRNAs namely MALAT1, linc-SLC22A2, linc-OBP2B-1, linc_luo_1172, linc-DHFRL1-4, SNHG15, linc-FAM98A-3, H19, MEG3, ANRIL, MIAT, and GAS5 are possibly involved in the pathogenesis of IS. Meanwhile, lots of miRNAs contribute in this process. Differential expression of lncRNAs and miRNAs in the sera of IS patients versus unaffected individuals has endowed these transcripts the aptitude to distinguish at risk patients. Despite conduction of comprehensive assays for evaluation of the influence of lncRNAs/miRNAs in the pathogenesis of IS, therapeutic impacts of these transcripts in IS have not been clarified. In the present paper, we review the impact of lncRNAs/miRNAs in the pathobiology of IS through assessment of evidence provided by human and animal studies.

Published in Frontiers in Aging Neuroscience

ISSN: 1663-4365 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/aging-neuroscience

About the journal

Abstract

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