A case of hemolytic-uremic syndrome with the development of catastrophic antiphospholipid syndrome: Diagnosis and clinical tactics

Abstract

The paper describes a case of practically simultaneous development of the hemolytic-uremic syndrome (HUS) and the catastrophic antiphospholipid syndrome (CAPS) complicated by mesenteric vessel thrombosis and small bowel necrosis. Multimodality treatment comprising volume plasmapheresis, fresh frozen plasma transfusion, hemodialysis, anticoagulant and disaggregant therapy could relieve thrombogenic events, such as pulmonary artery thromboembolism and intestinal necrosis.

Keywords

• hemolytic-uremic syndrome
• antiphospholipid syndrome
• catastrophic antiphospholipid syndrome
• acute renal failure
• thrombotic thrombocytopenic purpura
• antiphospholipid antibodies