Nature Communications (Apr 2017)

Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases

  • Hao Yu,
  • Patricia Dranchak,
  • Zhiru Li,
  • Ryan MacArthur,
  • Matthew S. Munson,
  • Nurjahan Mehzabeen,
  • Nathan J. Baird,
  • Kevin P. Battalie,
  • David Ross,
  • Scott Lovell,
  • Clotilde K. S. Carlow,
  • Hiroaki Suga,
  • James Inglese

DOI
https://doi.org/10.1038/ncomms14932
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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River blindness, a disease affecting millions throughout the tropics, is caused by parasitic worms. Here, Yuet al. report the discovery and structural characterization of potent macrocyclic peptide inhibitors of iPGM, a nematode-specific phosphoglycerate mutase, as potential leads for novel antimicrobial agents.