Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines

Lanying Du; Wanbo Tai; Yang Yang; Guangyu Zhao; Qing Zhu; Shihui Sun; Chang Liu; Xinrong Tao; Chien-Te K. Tseng; Stanley Perlman; Shibo Jiang; Yusen Zhou; Fang Li

doi:10.1038/ncomms13473

Nature Communications (Nov 2016)

Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines

Lanying Du,
Wanbo Tai,
Yang Yang,
Guangyu Zhao,
Qing Zhu,
Shihui Sun,
Chang Liu,
Xinrong Tao,
Chien-Te K. Tseng,
Stanley Perlman,
Shibo Jiang,
Yusen Zhou,
Fang Li

Affiliations

Lanying Du: Laboratory of Viral Immunology, Lindsley F. Kimball Research Institute, New York Blood Center
Wanbo Tai: Laboratory of Viral Immunology, Lindsley F. Kimball Research Institute, New York Blood Center
Yang Yang: Department of Pharmacology, University of Minnesota Medical School
Guangyu Zhao: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Qing Zhu: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Shihui Sun: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Chang Liu: Department of Pharmacology, University of Minnesota Medical School
Xinrong Tao: Department of Microbiology and Immunology and Center for Biodefense and Emerging Disease, University of Texas Medical Branch
Chien-Te K. Tseng: Department of Microbiology and Immunology and Center for Biodefense and Emerging Disease, University of Texas Medical Branch
Stanley Perlman: Department of Microbiology, University of Iowa
Shibo Jiang: Laboratory of Viral Immunology, Lindsley F. Kimball Research Institute, New York Blood Center
Yusen Zhou: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology
Fang Li: Department of Pharmacology, University of Minnesota Medical School

DOI: https://doi.org/10.1038/ncomms13473
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

Read online

Viral subunit vaccines contain epitopes that elicit non-neutralizing immune responses. Here, Duet al. mask an immunodominant non-neutralizing epitope on a MERS coronavirus subunit vaccine with a glycan probe, leading to significantly improved efficacy of the vaccine.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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