Lipids in Health and Disease (Sep 2008)

Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease

  • Hebbagodi Sridhara,
  • John Shibu,
  • Khadrinarasimhiah Natesha B,
  • Rao Veena S,
  • Perumal Ganapathy,
  • Shanker Jayashree,
  • Mukherjee Manjari,
  • Kakkar Vijay V

DOI
https://doi.org/10.1186/1476-511X-7-33
Journal volume & issue
Vol. 7, no. 1
p. 33

Abstract

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Abstract Background The APOA1-C3-A5 gene cluster plays an important role in the regulation of lipids. Asian Indians have an increased tendency for abnormal lipid levels and high risk of Coronary Artery Disease (CAD). Therefore, the present study aimed to elucidate the relationship of four single nucleotide polymorphisms (SNPs) in the Apo11q cluster, namely the -75G>A, +83C>T SNPs in the APOA1 gene, the Sac1 SNP in the APOC3 gene and the S19W variant in the APOA5 gene to plasma lipids and CAD in 190 affected sibling pairs (ASPs) belonging to Asian Indian families with a strong CAD history. Methods & results Genotyping and lipid assays were carried out using standard protocols. Plasma lipids showed a strong heritability (h2 48% – 70%; P P A (LOD score 2.77) SNPs by single-point analysis (P A (pi 0.56) and +83C>T (pi 0.52) (P P A SNPs along with hypertension showed maximized correlations with TC, TG and Apo B by association analysis. Conclusion The APOC3-Sac1 SNP is an important genetic variant that is associated with CAD through its interaction with plasma lipids and other standard risk factors among Asian Indians.