Acquired BCL2 variants associated with venetoclax resistance in acute myeloid leukemia

• Fiona C. Brown,
• Xin Wang,
• Richard Birkinshaw,
• Chong Chyn Chua,
• Thomas Morley,
• Sila Kasapgil,
• Giovanna Pomilio,
• Piers Blombery,
• David C. S. Huang,
• Peter Czabotar,
• Salvatore F. Priore,
• Guang Yang,
• Martin Carroll,
• Andrew H. Wei,
• Alexander E. Perl

Affiliations

Fiona C. Brown

Division of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia; Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia

Xin Wang

Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA

Richard Birkinshaw

Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia; Division of Structural Biology, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia

Chong Chyn Chua

Division of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia

Thomas Morley

Division of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia

Sila Kasapgil

Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia; Division of Structural Biology, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia

Giovanna Pomilio

Division of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia

Piers Blombery

Department of Pathology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia; Sir Peter Maccallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia; Department of Haematology, The Royal Melbourne Hospital, Melbourne, VIC, Australia

David C. S. Huang

Division of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia

Peter Czabotar

Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia; Division of Structural Biology, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia

Salvatore F. Priore

Division of Precision and Computational Diagnostics, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

Guang Yang

Division of Precision and Computational Diagnostics, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

Martin Carroll

Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA; Leukemia Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA

Andrew H. Wei

Division of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia; Department of Hematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, VIC, Australia; Andrew H. Wei. Division of Blood Cells and Blood Cancer, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;

Alexander E. Perl

Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA; Leukemia Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA; Correspondence: Alexander E. Perl, Division of Hematology-Oncology, Abramson Cancer Center, University of Pennsylvania, 3400 Civic Blvd, PCAM, 12-154 South Tower, Philadelphia, PA 19104;