Nature Communications (Jul 2020)

NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans

  • Myung-Kyu Choi,
  • He Liu,
  • Taihong Wu,
  • Wenxing Yang,
  • Yun Zhang

DOI
https://doi.org/10.1038/s41467-020-17218-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Neural plasticity underlies learning and is regulated by modulation of gap junctions. Here, the authors show that NMDAR- and CaMKII-mediated cell autonomous downregulation of gap junction molecules in a circuit of interneurons facilitates olfactory learning affecting behavior in C. elegans.