ANTIMICROBIAL PROPERTIES OF N-BENZOTIAZOL-2-YL-BENZENSULFONAMIDE AND THEIR ANALOGS WITH NUCLEOPHYLIC RADICALS

Abstract

It was shown that N-benzotiazol-2-yl-benzensulfonamide (compound I) and it derivatives with nucleophylic radicals (compounds II, III and IV) can inhibit in vitro S. аureus, P. аeruginosa and S. еnteritidis growth in depending on a dose. The inhibitory effect of these compounds on S. aureus did not depend on their structures. At the same time, the derivatives with nucleophylic radicals were more effective against gram-negative bacteria then compound I. In presence of para-aminobenzoic acid antimicrobial effect of the compound I decreased approximately by 40 %. For the compounds III and IV there were no any decreasing of antimicrobial activity detected in presence of PABA.

Keywords

• антимікробна активність
• n-бензотіазол-2-іл-бензенсульфонамід
• похідні з нуклеофільними замісниками
• антагонізм з параамінобензойною кислотою