OncoTargets and Therapy (Jul 2019)

Nanosomal docetaxel lipid suspension based chemotherapy in a pregnant MBC patient – a case report

  • Ramaswamy R,
  • Joshi N,
  • Khan MA,
  • Siddhara S

Journal volume & issue
Vol. Volume 12
pp. 5679 – 5685

Abstract

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Rajkumar Ramaswamy,1 Nisarg Joshi,2 Mujtaba A Khan,2 Seerin Siddhara11Department of Medical Oncology, Velammal Medical College and Research Institute, Madurai, Tamil Nadu 625009, India; 2Department of Medical Affairs & Clinical Development, Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat 380054, IndiaAbstract: The current report presents a case of a pregnant woman with breast cancer metastasized to liver and lungs. The standard of care for breast cancer in pregnancy is anthracycline/taxane-based chemotherapy regimens. Docetaxel has shown a favorable toxicity profile during the second and third trimesters of pregnancy. A novel nanosomal docetaxel lipid suspension (NDLS) (DoceAqualip), with a proven efficacy and tolerability profile, has been approved in India for the treatment of advanced solid tumors since 2013. We present here a case of a pregnant woman with metastatic breast cancer managed with NDLS based TAC regimen showing a partial response after six cycles. The patient delivered a healthy male child with normal Apgar score and weight at the 32nd week of gestation.Keywords: NDLS, PABC, DoceAqualip, pregnancy, breast cancer, metastatic

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