Cell & Bioscience (Mar 2023)
Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression
- Ruifang Sun,
- Yang Yang,
- Weidong Lü,
- Yanqi Yang,
- Yulong Li,
- Zhigang Liu,
- Dongmei Diao,
- Yang Wang,
- Su’e Chang,
- Mengnan Lu,
- Qiuyu Jiang,
- Bingling Dai,
- Xiaobin Ma,
- Chang’an Zhao,
- Moqi Lü,
- Juan Zhang,
- Caixia Ding,
- Na Li,
- Jian Zhang,
- Zhengtao Xiao,
- Dangxia Zhou,
- Chen Huang
Affiliations
- Ruifang Sun
- Department of Oncology Surgery, The First Affiliated Hospital of Xi’an Jiaotong University
- Yang Yang
- School of Public Health, Shaanxi University of Chinese Medicine
- Weidong Lü
- Department of Thoracic Surgery, Shaanxi Provincial Tumor Hospital, Xi’an Jiaotong University
- Yanqi Yang
- Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University
- Yulong Li
- Department of Gastroenterology, Shaanxi Provincial People’s Hospital
- Zhigang Liu
- Department of Thoracic Surgery, Shaanxi Provincial Tumor Hospital, Xi’an Jiaotong University
- Dongmei Diao
- Department of Oncology Surgery, The First Affiliated Hospital of Xi’an Jiaotong University
- Yang Wang
- Department of Oncology Surgery, The First Affiliated Hospital of Xi’an Jiaotong University
- Su’e Chang
- Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University
- Mengnan Lu
- Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University
- Qiuyu Jiang
- Department of Cell Biology and Genetics, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University
- Bingling Dai
- School of Pharmacy, Health Science Center, Xi’an Jiaotong University
- Xiaobin Ma
- Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University
- Chang’an Zhao
- Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University
- Moqi Lü
- Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University
- Juan Zhang
- Department of Pathology, Shaanxi Provincial Tumor Hospital, Xi’an Jiaotong University
- Caixia Ding
- Department of Pathology, Shaanxi Provincial Tumor Hospital, Xi’an Jiaotong University
- Na Li
- School of Pharmacy, Xinxiang Medical University
- Jian Zhang
- Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University
- Zhengtao Xiao
- Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University
- Dangxia Zhou
- Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University
- Chen Huang
- Department of Cell Biology and Genetics, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University
- DOI
- https://doi.org/10.1186/s13578-023-01002-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Highlights We performed single-cell transcriptome sequencing in one case carrying adenoma and carcinoma, and explored process of colon cancer progression. Results suggest the presence of dominant clones of same cells including C2 goblet cell, epithelial cell subtype 1 (Epi1), enterocyte cell subset 0 (Entero0), and Entero5 in colon carcinoma We discovered new colon cancer related genes including AC007952.4, NEK8, CHRM3, ANO7, B3GNT6, NEURL1, ODC1 and KCNMA1. The function of TBC1D4, LTB, C2CD4A, AND GBP4/5 in T cells needs to be clarified.
Keywords
