Non-coding RNA and reprogrammed mitochondrial metabolism in genitourinary cancer

Sandiya Thirunavukkarasu; Shouryarudra Banerjee; Ishaq Tantray; Ishaq Tantray; Rani Ojha

doi:10.3389/fgene.2024.1364389

Frontiers in Genetics (Mar 2024)

Non-coding RNA and reprogrammed mitochondrial metabolism in genitourinary cancer

Sandiya Thirunavukkarasu,
Shouryarudra Banerjee,
Ishaq Tantray,
Ishaq Tantray,
Rani Ojha

Affiliations

Sandiya Thirunavukkarasu: Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Shouryarudra Banerjee: Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Ishaq Tantray: InventX Scientia, Kashmir, India
Ishaq Tantray: Department of Pathology, School of Medicine, Stanford University, Stanford, CA, United States
Rani Ojha: Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

DOI: https://doi.org/10.3389/fgene.2024.1364389
Journal volume & issue: Vol. 15

Abstract

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Non-coding ribonucleic acids (ncRNAs) have been recently shown to contribute to tumorigenesis by mediating changes in metabolism. ncRNAs act as key molecules in metabolic pathways regulation. The dysregulation of ncRNAs during cancer progression contributes to altered metabolic phenotypes leading to reprogrammed metabolism. Since ncRNAs affect different tumor processes by regulating mitochondrial dynamics and metabolism, in the future ncRNAs can be exploited in disease detection, diagnosis, treatment, and resistance. The purpose of this review is to highlight the role of ncRNAs in mitochondrial metabolic reprogramming and to relate their therapeutic potential in the management of genitourinary cancer.

Published in Frontiers in Genetics

ISSN: 1664-8021 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://journal.frontiersin.org/journal/genetics

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Abstract

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