Case Reports in Hematology (Jan 2018)

Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma

  • Shin Nagai,
  • Junji Hiraga,
  • Noriyuki Suzuki,
  • Naruko Suzuki,
  • Yusuke Takagi,
  • Michihiko Narita,
  • Yoshitoyo Kagami

DOI
https://doi.org/10.1155/2018/1583925
Journal volume & issue
Vol. 2018

Abstract

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We report a rare case of composite lymphoma comprising extranodal NK/T-cell lymphoma, nasal type, (ENKL) and diffuse large B-cell lymphoma (DLBCL) in a 70-year-old man complaining of fatigue. Computed tomography showed multiple consolidations in both lungs, and ENKL was diagnosed from transbronchial lung biopsy. Positron emission tomography also detected abnormal uptake in the stomach, and DLBCL was diagnosed from subsequent gastroscopy. Two courses of chemotherapy including rituximab achieved reduction in DLBCL, but ENKL proved resistant to this treatment and progressed. Concomitant ENKL and DLBCL have not been previously described among reports of composite lymphomas.