Nature Communications (Oct 2016)

Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing

  • Parisa Kakanj,
  • Bernard Moussian,
  • Sebastian Grönke,
  • Victor Bustos,
  • Sabine A. Eming,
  • Linda Partridge,
  • Maria Leptin

DOI
https://doi.org/10.1038/ncomms12972
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 16

Abstract

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The TOR and insulin/IGF signalling (IIS) network are central responses to wound healing. Here the authors develop a technique of live imaging of laser-induced epidermal wounds to flies and show that TOR and IIS are independently required for wound healing, which may have implications for diabetic wound healing and its treatment.