Structural insights on TRPV5 gating by endogenous modulators

Taylor E. T. Hughes; Ruth A. Pumroy; Aysenur Torun Yazici; Marina A. Kasimova; Edwin C. Fluck; Kevin W. Huynh; Amrita Samanta; Sudheer K. Molugu; Z. Hong Zhou; Vincenzo Carnevale; Tibor Rohacs; Vera Y. Moiseenkova-Bell

doi:10.1038/s41467-018-06753-6

Nature Communications (Oct 2018)

Structural insights on TRPV5 gating by endogenous modulators

Taylor E. T. Hughes,
Ruth A. Pumroy,
Aysenur Torun Yazici,
Marina A. Kasimova,
Edwin C. Fluck,
Kevin W. Huynh,
Amrita Samanta,
Sudheer K. Molugu,
Z. Hong Zhou,
Vincenzo Carnevale,
Tibor Rohacs,
Vera Y. Moiseenkova-Bell

Affiliations

Taylor E. T. Hughes: Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
Ruth A. Pumroy: Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
Aysenur Torun Yazici: Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University
Marina A. Kasimova: Institute for Computational Molecular Science, Temple University
Edwin C. Fluck: Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
Kevin W. Huynh: California NanoSystems Institute, University of California
Amrita Samanta: Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
Sudheer K. Molugu: Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania
Z. Hong Zhou: California NanoSystems Institute, University of California
Vincenzo Carnevale: Institute for Computational Molecular Science, Temple University
Tibor Rohacs: Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University
Vera Y. Moiseenkova-Bell: Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-018-06753-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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TRPV5 is a kidney specific transient receptor potential (TRP) channel with an important role in calcium reabsorption. Here the authors provide mechanistic insights into TRPV5 modulation by determining the phosphatidylinositol 4,5-bisphosphate and calmodulin bound TRPV5 cryo-EM structures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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