Ovarian clear cell carcinoma with uterine intramural recurrence: Case report of ovarian clear cell carcinoma with fertility sparing treatment

Ting Yu Chang; Chiung-Yi Yeh; Chih-Yi Yang; Wu-Chou Lin; Chien-Chu Huang; Yao-Ching Hung

Taiwanese Journal of Obstetrics & Gynecology (Jan 2024)

Ovarian clear cell carcinoma with uterine intramural recurrence: Case report of ovarian clear cell carcinoma with fertility sparing treatment

Ting Yu Chang,
Chiung-Yi Yeh,
Chih-Yi Yang,
Wu-Chou Lin,
Chien-Chu Huang,
Yao-Ching Hung

Affiliations

Ting Yu Chang: Department of Obstetrics and Gynecology, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taichung, Taiwan
Chiung-Yi Yeh: Department of Obstetrics and Gynecology, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taichung, Taiwan; Graduate Institution of Biomedical Sciences, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taichung, Taiwan
Chih-Yi Yang: Department of Obstetrics and Gynecology, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taichung, Taiwan; Department of Public Health, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taichung, Taiwan
Wu-Chou Lin: Department of Obstetrics and Gynecology, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taichung, Taiwan; Department of Medicine, China Medical University, Taichung, Taiwan
Chien-Chu Huang: Department of Obstetrics and Gynecology, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taichung, Taiwan; Corresponding author.
Yao-Ching Hung: Department of Obstetrics and Gynecology, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taichung, Taiwan; Graduate Institution of Biomedical Sciences, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taichung, Taiwan; Department of Obstetrics and Gynecology, Asia University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taichung, Taiwan; Corresponding author. Department of Obstetrics and Gynecology, China Medical University Hospital, No. 2, Yuh-Der Road, Taichung 404, Taichung, Taiwan.

Journal volume & issue: Vol. 63, no. 1
pp. 90 – 94

Abstract

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Objective: Ovarian clear cell carcinoma has a poor prognosis in comparison with other pathological types of epithelial ovarian carcinoma. It also has relative resistance to first-line platinum-based chemotherapy with a great risk of recurrence. Case report: We report a case of recurrent ovarian clear cell carcinoma status after left salpingo-oophorectomy (fertility-sparing debulking operation) and six courses of adjuvant chemotherapy (paclitaxel (175 mg/m2)/carboplatin (AUC 6)). However, two years after diagnosis, elevated CA-125 accompanied by an intrapelvic mass was noted. Uterine intramural recurrence was found during the second laparotomy. She was treated with right salpingo-oophorectomy and abdominal hysterectomy combined with systemic chemotherapy administration (paclitaxel (175 mg/m2)/carboplatin (AUC 6)) and maintenance therapy (bevacizumab (7.5 mg/kg)). There was no other recurrence until one and a half years postoperatively, and the patient was tumor free with regular follow-up. Conclusion: In young patients with stage I ovarian clear cell carcinoma, fertility-sparing surgery was considered. Most patients will suffer from tumor recurrence, and also intrauterine recurrence rarely happen.

Published in Taiwanese Journal of Obstetrics & Gynecology

ISSN: 1028-4559 (Print)
Publisher: Elsevier
Country of publisher: Taiwan, Province of China
LCC subjects: Medicine: Gynecology and obstetrics
Website: http://www.journals.elsevier.com/taiwanese-journal-of-obstetrics-and-gynecology/

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