Molbank
(Jun 2020)
6-Hydroxy-2-methylbenzofuran-4-carboxylic Acid
Matteo Mori,
Fiorella Meneghetti,
Laurent R. Chiarelli,
Alessia Diego,
Donatella Nava,
Arianna Gelain,
Giulia Cazzaniga,
Stefania Villa,
Elena Pini
Affiliations
Matteo Mori
Department of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy
Fiorella Meneghetti
Department of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy
Laurent R. Chiarelli
Department of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, via A. Ferrata 9, 27100 Pavia, Italy
Alessia Diego
Department of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy
Donatella Nava
Department of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy
Arianna Gelain
Department of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy
Giulia Cazzaniga
Department of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy
Stefania Villa
Department of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy
Elena Pini
Department of Pharmaceutical Sciences, University of Milan, via L. Mangiagalli 25, 20133 Milano, Italy
DOI
https://doi.org/10.3390/M1143
Journal volume & issue
Vol. 2020,
no. 2
Abstract
Read online
6-Hydroxy-2-methylbenzofuran-4-carboxylic acid was synthesized in two steps, starting from 3,5-dihydroxybenzoate. The product was obtained through a direct thermal one-pot cyclization with propargyl bromide, followed by a base-catalyzed hydrolysis. Its molecular structure was elucidated by means of mono- and bidimensional NMR techniques, ESI-MS, FT-IR and single-crystal X-ray diffraction.
Keywords
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