6-Hydroxy-2-methylbenzofuran-4-carboxylic Acid

Abstract

6-Hydroxy-2-methylbenzofuran-4-carboxylic acid was synthesized in two steps, starting from 3,5-dihydroxybenzoate. The product was obtained through a direct thermal one-pot cyclization with propargyl bromide, followed by a base-catalyzed hydrolysis. Its molecular structure was elucidated by means of mono- and bidimensional NMR techniques, ESI-MS, FT-IR and single-crystal X-ray diffraction.

Keywords

• 6-hydroxy-2-methylbenzofuran-4-carboxylic acid methyl ester
• 6-hydroxy-2-methylbenzofuran-4-carboxylic acid
• COSY
• NOESY
• HSQC
• HMBC