Nature Communications (Feb 2022)

Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer

  • I.-M. Launonen,
  • N. Lyytikäinen,
  • J. Casado,
  • E. A. Anttila,
  • A. Szabó,
  • U.-M. Haltia,
  • C. A. Jacobson,
  • J. R. Lin,
  • Z. Maliga,
  • B. E. Howitt,
  • K. C. Strickland,
  • S. Santagata,
  • K. Elias,
  • A. D. D’Andrea,
  • P. A. Konstantinopoulos,
  • P. K. Sorger,
  • A. Färkkilä

DOI
https://doi.org/10.1038/s41467-022-28389-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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The tumour microenvironment has not been fully characterised in high-grade serous ovarian cancers (HGSOC). Here, the authors use highly multiplexed imaging to analyse the HGSOC immune microenvironment at spatial and single-cell resolution, with clinically relevant findings for BRCA1/2-mutated tumours.