Diabetes, Metabolic Syndrome and Obesity (Nov 2019)
Abdominal Fat Is Directly Associated With Inflammation In Persons With Type-2 Diabetes Regardless Of Glycemic Control – A Jordanian Study
Abstract
Hiba Bawadi,1 Rami Katkhouda,2 Reema Tayyem,3 Abdelhamid Kerkadi,1 Samira Bou Raad,4 Hadil Subih5 1Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha, Qatar; 2Department of Nutrition and Food Technology, Jordan University of Science and Technology, Irbid, Jordan; 3Department of Clinical Nutrition and Dietetics, University of Jordan, Amman, Jordan; 4Department of Nutrition and Food Science, American University of Science and Technology, Beirut, Lebanon; 5Department of Nutrition and Food Technology, Jordan University of Science and Technology, Irbid, JordanCorrespondence: Hiba BawadiHuman Nutrition Department, College of Health Sciences, QU-Health, Qatar University, Building I06, University Street, PO Box 2713, Doha, QatarTel +97444034801Email [email protected] and aim: Systemic inflammation is related to the progression of complications associated with diabetes. This study aimed to investigate the association between general and abdominal obesity and inflammation in patients with type-2 diabetes with or without glycemic control.Methods: A total of 198 men (n=73) and women (n=125) diagnosed with type 2 diabetes participated in this study. General obesity markers, body mass index (BMI), and abdominal fat were assessed. Circulating concentrations of glycated hemoglobin (HbA1C), C-reactive protein (CRP), and serum interleukin-6 (IL-6) were determined. Poor glycemic control and good glycemic control were defined as having fasting HbA1C concentrations ≥7% and <7%, respectively. Multivariate adjusted analysis of covariance was used to determine the relation between BMI and abdominal fat and markers of inflammation in patients with good and poor glycemic control.Results: Patients in <7% HbA1C category, those with high abdominal fat had ≈262% higher CRP and ≈30.6% higher IL-6 compared to those with low abdominal fat (p˂0.05). Patients in ≥7% HbA1C category, those with high abdominal fat had ≈41.4% higher CRP and ≈33.9% higher IL-6 compared to those with low abdominal fat (p˂0.05). Abdominal fat was directly related to CRP (p˂0.023) and IL-6 (p˂0.002) concentrations in both groups of type-2 diabetic patients with <7% and ≥7% HbA1C. In patients with ≥7% HbA1C, BMI was directly related to CRP (p˂0.02) and IL-6 (p˂0.047). Whereas in patients with <7% HbA1C, BMI was not associated with CRP or IL-6 concentrations.Conclusion: High level of abdominal fat is associated with systemic inflammation in type-2 diabetes regardless of glycemic control. Abdominal fat is a better predictor (determinant) of inflammation than BMI in patients with type-2 diabetes with or without glycemic control.Keywords: BMI, C-reactive protein, diabetes, IL-6, inflammation, obesity
