Neural Regeneration Research (Jan 2015)
Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury
- Xiao-ge Yan,
- Bao-hua Cheng,
- Xin Wang,
- Liang-cai Ding,
- Hai-qing Liu,
- Jing Chen,
- Bo Bai
Affiliations
- Xiao-ge Yan
- Bao-hua Cheng
- Xin Wang
- Liang-cai Ding
- Hai-qing Liu
- Jing Chen
- Bo Bai
- DOI
- https://doi.org/10.4103/1673-5374.157243
- Journal volume & issue
-
Vol. 10,
no. 5
pp. 766 – 771
Abstract
Apelin-13 inhibits neuronal apoptosis caused by hydrogen peroxide, yet apoptosis following cerebral ischemia-reperfusion injury has rarely been studied. In this study, Apelin-13 (0.1 µg/g) was injected into the lateral ventricle of middle cerebral artery occlusion model rats. TTC, TUNEL, and immunohistochemical staining showed that compared with the cerebral ischemia/reperfusion group, infarct volume and apoptotic cell number at the ischemic penumbra region were decreased in the Apelin-13 treatment group. Additionally, Apelin-13 treatment increased Bcl-2 immunoreactivity and decreased caspase-3 immunoreactivity. Our findings suggest that Apelin-13 is neuroprotective against cerebral ischemia/reperfusion injury through inhibition of neuronal apoptosis.
Keywords
- active zone stability
- Drosophila
- neuromuscular junction
- dephosphorylation
- Liprin-α
- Syd-1
- PP2A
- GSK-3ß
- living scaffolds
- neural tissue engineering
- cell transplant
- biomaterials
- regeneration
- neurotrauma
- neurodegeneration
- axon pathfinding
- cell migration
- injury
- plasticity
- neurodegenerative disease
- brain
- therapy
- neuron
- microglia
- neural progenitor
- tissue engineering
- neuroregeneration
- repair
- central nervous system
- biomaterial
- regenerative medicine
- nanotechnology
- spinal cord injury
- axonal regeneration
- exosome
- extracellular vesicle
- microRNA
- microvesicle
- nerve gap
- neurite outgrowth
- peripheral nerve injury
- Schwann cell
- stem cell
- hemodynamic phases
- cerebral subarachnoid hemorrhage
- metabolic crises
- nerve regeneration
- hypoxic-ischemic brain damage
- ginsenoside Rg1
- neural stem cells
- cell transplantation
- cell differentiation
- cognition
- nerve reconstruction
- neural regeneration
- nerve regeneration
- brain injury
- neuroimaging
- functional magnetic resonance imaging
- regional homogeneity
- apoplexy
- subacute
- ischemia
- participants
- healthy
- volunteers
- brain activity
- NSFC grants
- neural regeneration
- nerve regeneration
- brain injury
- neuroprotection
- cerebral ischemia/reperfusion injury
- lateral intracerebroventricular injection
- Apelin-13
- nerve apoptosis
- Bcl-2
- caspase-3
- NSFC grants
- neural regeneration
