Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer

H. Y. Chow; B. Dong; C. A. Valencia; C. T. Zeng; J. N. Koch; T. Y. Prudnikova; J. Chernoff

doi:10.1038/s41467-018-05935-6

Nature Communications (Aug 2018)

Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer

H. Y. Chow,
B. Dong,
C. A. Valencia,
C. T. Zeng,
J. N. Koch,
T. Y. Prudnikova,
J. Chernoff

Affiliations

H. Y. Chow: Cancer Center, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy
B. Dong: Cancer Center, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy
C. A. Valencia: Division of Human Genetics, Cincinnati Children’s Hospital Medical Center
C. T. Zeng: Cancer Center, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy
J. N. Koch: Cancer Biology Program, Fox Chase Cancer Center
T. Y. Prudnikova: Cancer Biology Program, Fox Chase Cancer Center
J. Chernoff: Cancer Biology Program, Fox Chase Cancer Center

DOI: https://doi.org/10.1038/s41467-018-05935-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Group I Paks, like Pak1, are required for the activation of several key oncogenic signaling pathways. Here the authors study an inducible peptide mimicking the auto-inhibitory domain of Pak1 and show promising anti-tumor effects in a mouse model of colorectal cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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