Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling

Adam T. Waickman; Kaitlin Victor; Tao Li; Kristin Hatch; Wiriya Rutvisuttinunt; Carey Medin; Benjamin Gabriel; Richard G. Jarman; Heather Friberg; Jeffrey R. Currier

doi:10.1038/s41467-019-11634-7

Nature Communications (Aug 2019)

Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and metabolic profiling

Adam T. Waickman,
Kaitlin Victor,
Tao Li,
Kristin Hatch,
Wiriya Rutvisuttinunt,
Carey Medin,
Benjamin Gabriel,
Richard G. Jarman,
Heather Friberg,
Jeffrey R. Currier

Affiliations

Adam T. Waickman: Viral Diseases Branch, Walter Reed Army Institute of Research
Kaitlin Victor: Viral Diseases Branch, Walter Reed Army Institute of Research
Tao Li: Viral Diseases Branch, Walter Reed Army Institute of Research
Kristin Hatch: Viral Diseases Branch, Walter Reed Army Institute of Research
Wiriya Rutvisuttinunt: Viral Diseases Branch, Walter Reed Army Institute of Research
Carey Medin: Department of Cell and Molecular Biology, Institute for Immunology and Informatics, University of Rhode Island
Benjamin Gabriel: Department of Cell and Molecular Biology, Institute for Immunology and Informatics, University of Rhode Island
Richard G. Jarman: Viral Diseases Branch, Walter Reed Army Institute of Research
Heather Friberg: Viral Diseases Branch, Walter Reed Army Institute of Research
Jeffrey R. Currier: Viral Diseases Branch, Walter Reed Army Institute of Research

DOI: https://doi.org/10.1038/s41467-019-11634-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Using a combination of single-cell RNA sequencing and TCR clonotype analysis on longitudinal samples from dengue vaccinated individuals, Waickman et al. here define a transcriptional signature in acutely-activated T cells that is associated with durable CD8+ T cell memory.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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