Malignant Transformation of Juvenile Nasopharyngeal Angiofibroma in a Non-irradiated Case: A Rarity Denuded

Abstract

Nasopharyngeal angiofbroma is a relatively rare tumor, which is locally aggressive and histologically benign with transformation to a malignant sarcomatous form in a previously irradiated candidate. Here we are reporting the second known case according to literature ofma non irradiated case of nasopharyngeal angiofbroma who was previously operated 11 times for the excision of nasopharyngeal angiofbroma. All the previous biopsy reports were proven to be of nasopharyngeal angiofbroma, but for the last time, when he was operated at our center, biopsy showed malignant transformation of nasopharyngeal angiofbroma. The patient was then subjected to intensity modulated radiotherapy and is in close surveillance, doing well till date.Hence this case presentation gives an insight about malignant transformation of nasopharyngeal angiofbroma in absence of irradiation, which is a very rare entity.