Nature Communications (Aug 2018)
Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy
- Susan E. Logue,
- Eoghan P. McGrath,
- Patricia Cleary,
- Stephanie Greene,
- Katarzyna Mnich,
- Aitor Almanza,
- Eric Chevet,
- Róisín M. Dwyer,
- Anup Oommen,
- Patrick Legembre,
- Florence Godey,
- Emma C. Madden,
- Brian Leuzzi,
- Joanna Obacz,
- Qingping Zeng,
- John B. Patterson,
- Richard Jäger,
- Adrienne M. Gorman,
- Afshin Samali
Affiliations
- Susan E. Logue
- Apoptosis Research Centre, National University of Ireland Galway
- Eoghan P. McGrath
- Apoptosis Research Centre, National University of Ireland Galway
- Patricia Cleary
- Apoptosis Research Centre, National University of Ireland Galway
- Stephanie Greene
- Fosun Orinove PharmaTech Inc.
- Katarzyna Mnich
- Apoptosis Research Centre, National University of Ireland Galway
- Aitor Almanza
- Apoptosis Research Centre, National University of Ireland Galway
- Eric Chevet
- Inserm U1242, Chemistry Oncogenesis Stress Signaling, Université de Rennes 1
- Róisín M. Dwyer
- LAM 2015, Discipline of Surgery, Lambe Institute for Translational Research, National University of Ireland Galway
- Anup Oommen
- School of Natural Sciences, National University of Ireland Galway
- Patrick Legembre
- Inserm U1242, Chemistry Oncogenesis Stress Signaling, Université de Rennes 1
- Florence Godey
- Inserm U1242, Chemistry Oncogenesis Stress Signaling, Université de Rennes 1
- Emma C. Madden
- Apoptosis Research Centre, National University of Ireland Galway
- Brian Leuzzi
- Apoptosis Research Centre, National University of Ireland Galway
- Joanna Obacz
- Inserm U1242, Chemistry Oncogenesis Stress Signaling, Université de Rennes 1
- Qingping Zeng
- Fosun Orinove PharmaTech Inc.
- John B. Patterson
- Fosun Orinove PharmaTech Inc.
- Richard Jäger
- Hochschule Bonn-Rhein-Sieg, University of Applied Sciences, Department of Natural Sciences
- Adrienne M. Gorman
- Apoptosis Research Centre, National University of Ireland Galway
- Afshin Samali
- Apoptosis Research Centre, National University of Ireland Galway
- DOI
- https://doi.org/10.1038/s41467-018-05763-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to confer potent anti-tumor effects in TNBC.
